P/Q-type voltage-gated calcium channel antibodies in paraneoplastic disorders of the central nervous system Journal Article

  

Authors:	Voltz, R.; Carpentier, A. F.; Rosenfeld, M. R.; Posner, J. B.; Dalmau, J.
Article Title:	P/Q-type voltage-gated calcium channel antibodies in paraneoplastic disorders of the central nervous system
Abstract:	Whether P/Q-type voltage-gated calcium channel (VGCC) antibodies are present in the serum of patients with paraneoplastic syndromes other than the Lambert-Eaton myasthenic syndrome (LEMS) and tumors other than small-cell lung cancer (SCLC) is controversial. Using a commercially available radioimmunoprecipitation assay kit, we examined the sera of 93 patients with paraneoplastic syndromes of the central nervous system (CNS), including 27 patients with paraneoplastic cerebellar degeneration (PCD) associated with tumors other than SCLC and 66 SCLC patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/SN). All PCD sera from patients with tumors other than SCLC were negative for P/Q-type VGCC antibodies. Eight of 66 (12%) SCLC patients with PEM/SN had P/Q-type VGCC antibodies; 4 had LEMS and the other 4 had no symptoms of LEMS or they were overlooked and, therefore, not examined electrophysiologically. In patients with paraneoplastic syndromes of the CNS, the detection of P/Q-type VGCC antibodies supports the diagnosis of LEMS; in our series, only 6% of patients with SCLC and PEM/SN may have had a false positive antibody result, or undiagnosed LEMS.
Keywords:	controlled study; human cell; major clinical study; neoplasms; tumor marker; central nervous system; lung small cell cancer; blood analysis; immunoassay; eaton lambert syndrome; myasthenia gravis; paraneoplastic syndrome; autoantibodies; carcinoma, small cell; neurodegenerative diseases; radioimmunoassay; antibody blood level; cerebellar diseases; encephalomyelitis; radioimmunoprecipitation; central nervous system diseases; paraneoplastic syndromes; correlation function; calcium channel; calcium channels; cerebellum degeneration; humans; human; female; priority journal; article; lambert-eaton myasthenic syndrome; paraneoplastic neurological disorders; anti-hu; p/q-type voltage-gated calcium channel antibodies; paraneoplastlc cerebellar degeneration; voltage gated channel forming protein; calcium channels, n-type
Journal Title:	Muscle and Nerve
Volume:	22
Issue:	1
ISSN:	0148-639X
Publisher:	John Wiley & Sons
Date Published:	1999-01-01
Start Page:	119
End Page:	122
Language:	English
DOI:	10.1002/(sici)1097-4598(199901)22:1<119::aid-mus19>3.0.co;2-5
PUBMED:	9883867
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032889460&partnerID=40&md5=fc9c348ddef5bc39a842509ca30c2c32
Notes:	Article -- Export Date: 16 August 2016 -- Source: Scopus

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