Anti-Hu antibodies in patients with small-cell lung cancer: Association with complete response to therapy and improved survival Journal Article
| Authors: | Graus, F.; Dalmau, J.; Reñé, R.; Torà, M.; Malats, N.; Verschuuren, J. J.; Cardenal, F.; Viñolas, N.; delMuro, J. G.; Vadell, C.; Mason, W. P.; Rosell, R.; Posner, J. B.; Real, F. X. |
| Article Title: | Anti-Hu antibodies in patients with small-cell lung cancer: Association with complete response to therapy and improved survival |
| Abstract: | Purpose: Anti-Hu antibodies (HuAb) recognise antigens expressed by neurons and small-cell lung cancer (SCLC). High titers of HuAb were initially reported in serum from patients with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/SN) and SCLC. Preliminary studies have indicated that some SCLC patients without PEM/SN harbor low titer of HuAb in their serum, and that the SCLC of these patients may grow more indolently. Based on these observations, we conducted a multicenter prospective study of SCLC patients without PEM/SN to determine the incidence and prognostic implications of HuAb. Methods: Serum samples were collected at diagnosis of SCLC in 196 patients without PEM/SN. HuAb were determined by immunoblot of purified recombinant Hug antigen. Results: HuAb were detected in 32 (16%) of the 196 patients. Of the 170 patients who received treatment for the tumor, 27 (16%) were HuAb positive. HuAb was associated with limited disease stage (59.3% v 38.6%; P = .047), complete response to therapy (55.6% v 19.6%; P <.001), and longer survival (14.9 v 10.2 months; P = .018). In a logistic regression analysis, HuAb status was an independent predictor of complete response induction. The probability of achieving a complete response was more than five times higher in HuAb-positive than in HuAb-negative patients (odds ratio, 5.4; 95% confidence interval, 1.71 to 16.89; P=.004). Cox multivariate analysis indicated that HuAb status was not independently associated with survival. Conclusion: The presence of HuAb at diagnosis of SCLC is a strong and independent predictor of complete response to treatment. This feature accounts for the association between HuAb and longer survival. (C) 1997 by American Society of Clinical Oncology. |
| Keywords: | chemotherapy; prognostic factors; carcinoma; tumor; expression; regression; lines; messenger-rna; sensory neuronopathy; paraneoplastic encephalomyelitis antigen |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 15 |
| Issue: | 8 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1997-08-01 |
| Start Page: | 2866 |
| End Page: | 2872 |
| Language: | English |
| ACCESSION: | WOS:A1997XN95400014 |
| PROVIDER: | wos |
| PUBMED: | 9256130 |
| DOI: | 10.1200/JCO.1997.15.8.2866 |
| Notes: | Article -- Source: Wos |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work