A role for transcriptional repressors in targeting the yeast Swi/Snf complex Journal Article
| Authors: | Dimova, D.; Nackerdien, Z.; Furgeson, S.; Eguchi, S.; Osley, M. A. |
| Article Title: | A role for transcriptional repressors in targeting the yeast Swi/Snf complex |
| Abstract: | Genetic and biochemical studies indicate that the evolutionarily conserved Swi/Snf complex acts at a subset of genes to help transcriptional activators function on chromatin templates. The mechanism by which this complex is targeted to specific chromosomal loci remains unknown. We show that Swi/Snf is required for expression of the yeast histone HTA1-HTB1 locus because of the role of Hir1p and Hir2p corepressors in negatively regulating transcription. Snf5p, Snf2p/Swi2p, and Swi3p, three components of the yeast Swi/Snf complex, coimmunoprecipitate with each Hir protein, and Snf5p is maximally associated with the HTA1HTB1 promoter when the Hir-based repression system is intact and the Swi/Snf complex is functional. The data support a role for the Hir repressors in the genespecific targeting of Swi/Snf. |
| Keywords: | mutation; dna-binding proteins; nonhuman; chromosomal proteins, non-histone; gene expression; transcription, genetic; transcription factors; evolution, molecular; nuclear proteins; gene expression regulation; transcription regulation; saccharomyces cerevisiae; immunoprecipitation; trans-activators; yeast; saccharomyces cerevisiae proteins; repressor proteins; histones; gene expression regulation, fungal; fungal proteins; fungal genetics; promoter regions (genetics); article |
| Journal Title: | Molecular Cell |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 1097-2765 |
| Publisher: | Cell Press |
| Date Published: | 1999-07-01 |
| Start Page: | 75 |
| End Page: | 83 |
| Language: | English |
| DOI: | 10.1016/s1097-2765(00)80189-6 |
| PUBMED: | 10445029 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work