Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy Journal Article
| Authors: | Uckun, F. M.; Nachman, J. B.; Sather, H. N.; Sensel, M. G.; Kraf, P.; Steinherz, P. G.; Lange, B.; Hutchinson, R.; Reaman, G. H.; Gaynon, P. S.; Heerema, N. A. |
| Article Title: | Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy |
| Abstract: | Children with Philadelphia (Ph) chromosome positive (+) acute lymphoblastic leukemia (ALL) represent a subgroup at very high risk for treatment failure. This study included 1322 children enrolled between 1988 and 1994 on CCG risk-adjusted studies for ALL who had centrally reviewed cytogenetic data. Thirty patients had a t(9;22) and are referred to as Ph+, 1292 were Ph-. 23 of these 30 patients were treated on the CCG-1882 high risk ALL protocol. The event-free survival (EFS) outcome in CCG-1882 was significantly worse for Ph+ compared with Ph- patients, with 4-year estimates of 11.3% (SD = 9.8%) and 73.4% (SD = 2.3%), respectively (p < 0.0001). |
| Keywords: | adolescent; adult; child; treatment outcome; child, preschool; disease-free survival; survival rate; treatment failure; major clinical study; antineoplastic agents; cohort studies; cytogenetics; acute lymphoblastic leukemia; infant; children; childhood leukemia; philadelphia 1 chromosome; philadelphia chromosome; antileukemic agent; genes, abl; leukemia, lymphocytic, acute, l1; chromosome translocation 22; humans; prognosis; human; priority journal; article; chromosome translocation 9 |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 33 |
| Issue: | 1-2 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 1999-01-01 |
| Start Page: | 101 |
| End Page: | 106 |
| Language: | English |
| PUBMED: | 10194126 |
| PROVIDER: | scopus |
| DOI: | 10.3109/10428199909093730 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
