| Abstract: |
The intermediate in the preparation of 1,3,7,10- tetrahydroxybenzo[b]naphtho[2,3-d]furan-6,11-dione (2), 2-chloro-5,8- dimethoxy-3-(3,5-dimethoxyphenoxy)-1,4-naphthoquinone (8h), and corresponding hydroxyl, methoxyl, and acetoxyl analogues was found to possess interesting inhibitory activities in a number of cytotoxic test systems. Activities were also noticed in some 5,8-dihydroxy-1,4-naphthoquinone derivatives. A structure-activity discussion of compounds of this series is presented. The newly uncovered biological activity of 2-chloro-3-(substituted phenoxyl)- 1,4-naphthoquinones and 2,3-bis(substituted phenoxy)-1,4-naphthoquinones may suggest an approach for the development of new classes of antineoplastic agents. |
| Keywords: |
unclassified drug; human cell; antineoplastic agents; antineoplastic activity; drug structure; drug effect; drug screening; drug design; drug synthesis; structure activity relation; structure-activity relationship; magnetic resonance spectroscopy; naphthalenes; human; article; naphthoquinones; 1,4 naphthoquinone derivative; 1,3,7,10 tetrahydroxybenzo[b]naphtho[2,3 d]furan 6,11 dione; 2 chloro 5,8 dimethoxy 3 (3,5 dimethoxyphenoxy) 1,4 naphthoquinone
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