Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines Journal Article
| Authors: | Ramajayam, R.; Giridhar, R.; Yadav, M. R.; Balaraman, R.; Djaballah, H.; Shum, D.; Radu, C. |
| Article Title: | Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines |
| Abstract: | The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway. © 2007 Elsevier Masson SAS. All rights reserved. |
| Keywords: | controlled study; unclassified drug; human cell; nonhuman; antineoplastic agents; cell proliferation; animals; antineoplastic activity; drug structure; cell line, tumor; drug synthesis; acetylsalicylic acid; rat; rats; ic 50; inhibitory concentration 50; arachidonic acid; reaction analysis; antithrombocytic agent; leukemia cell line; thrombocyte aggregation inhibition; antileukemic agent; antileukemic; antiplatelet activity; diaryldiazepines; 2 (2 chlorophenyl) 3 (4' chlororophenyl) 6,7 dihydro 5h 1,4 diazepine; 2 (4 chlorophenyl) 3 (4' fluorophenyl) 6,7 dihydro 5h 1,4 diazepine; 6,7 dihydro 5h 1,4 diazepine derivative; diazepine derivative; azepines; platelet aggregation; platelet aggregation inhibitors |
| Journal Title: | European Journal of Medicinal Chemistry |
| Volume: | 43 |
| Issue: | 9 |
| ISSN: | 0223-5234 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-09-01 |
| Start Page: | 2004 |
| End Page: | 2010 |
| Language: | English |
| DOI: | 10.1016/j.ejmech.2007.11.023 |
| PUBMED: | 18191304 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: EJMCA" - "Source: Scopus" |
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