Polyspecific self-reactive antibodies in individuals infected with human immunodeficiency virus facilitate T cell deletion and inhibit costimulatory accessory cell function Journal Article
| Authors: | Wang, Z. Q.; Horowitz, H. W.; Orlikowsky, T.; Hahn, B. I.; Trejo, V.; Bapat, A. S.; Mittler, R. S.; Rayanade, R. J.; Young Yang, S.; Hoffmann, M. K. |
| Article Title: | Polyspecific self-reactive antibodies in individuals infected with human immunodeficiency virus facilitate T cell deletion and inhibit costimulatory accessory cell function |
| Abstract: | Self-reactive polyspecific IgG antibodies (PSAs) arise in human immunodeficiency virus (HIV)-seropositive subjects before they develop AIDS. Self-reactive PSA levels correlate with the destruction of CD8 T cells in HiV-infected individuals and mediate the antibody-dependent cellular toxicity-based destruction of human T cells in tissue culture. PSAs react across the species barrier and bind to T cell antigens in mice. Such reactivity with mouse lymphocytes was not detected in normal human serum. Injection of human PSA IgG causes massive T cell depletion in the spleen, lymph nodes, and thymus in mice: evidence that PSA IgG facilitates T cell destruction in vivo. In addition to facilitating macrophage cytotoxicity, self-reactive PSA IgG inhibits the macrophage-mediated activation of T cells with antigen receptor-specific monoclonal antibody or with antigen. Exogenous costimulatory stimuli or interleukin (IL)-12 can reverse the inhibition. In contrast, exogenous IL-10 mimics this inhibition. These data implicate PSA IgG as a pathogenic factor in the development of HIV disease. |
| Keywords: | clinical article; controlled study; human cell; human immunodeficiency virus infection; cd8-positive t-lymphocytes; animals; mice; interleukin 10; mice, inbred balb c; immune tolerance; immunoglobulin g; receptors, antigen, t-cell; antibody response; reference values; immunomodulation; human immunodeficiency virus; hiv seronegativity; acquired immunodeficiency syndrome; autoantibodies; lymphopenia; t lymphocyte activation; lymphocyte depletion; interleukin 12; hiv infections; hiv seropositivity; interleukin-12; humans; human; female; priority journal; article |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 180 |
| Issue: | 4 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 1999-10-01 |
| Start Page: | 1072 |
| End Page: | 1079 |
| Language: | English |
| DOI: | 10.1086/314974 |
| PUBMED: | 10479133 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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