Outcome for cancer patients requiring mechanical ventilation Journal Article
| Authors: | Groeger, J. S.; Peter Jr, W.; Nierman, D. M.; Glassman, J.; Shi, W.; Horak, D.; Price, K. |
| Article Title: | Outcome for cancer patients requiring mechanical ventilation |
| Abstract: | Purpose: To describe hospital survival for cancer patients who require mechanical ventilation. Materials and Methods: A prospective, multicenter observational study was performed at five academic tertiary care hospitals. Demographic and clinical variables were obtained on consecutive cancer patients at initiation of mechanical ventilation, and information on vital status at hospital discharge was acquired. Results: Our analysis was based on 782 adult cancer patients who met predetermined inclusion criteria. The overall observed hospital mortality was 76%, with no statistically significant differences among the five study centers. Seven variables (intubation after 24 hours, leukemia, progression or recurrence of cancer, allogeneic bone marrow transplantation, cardiac arrhythmias, presence of disseminated intravascular coagulation, and need for vasopressor therapy) were associated with an increased risk of death, whereas prior surgery with curative intent was protective. The predictive model based on these variables had an area under the receiver operating characteristic curve of 0.736, with Hosmer-Lemeshow goodness-of-fit statistics of 7.19; P = .52. Conclusion: This model can be used to estimate the probability of hospital survival for classes of adult cancer patients who require mechanical ventilation and can help to guide physicians, patients, and families in deciding goals and direction of treatment. Prospective independent validation in different medical settings is warranted. |
| Keywords: | adult; cancer survival; treatment outcome; middle aged; major clinical study; clinical trial; mortality; cancer recurrence; cancer growth; prospective studies; neoplasms; logistic models; allogenic bone marrow transplantation; intensive care; hospitalization; probability; multicenter study; malignant neoplastic disease; heart arrhythmia; regression analysis; dopamine; fibrinogen; respiratory insufficiency; noradrenalin; artificial ventilation; intubation; d dimer; hypertensive agent; fibrin; phenylephrine; adrenalin; dobutamine; fibrin degradation product; respiration, artificial; nitroprusside sodium; disseminated intravascular clotting; humans; human; male; female; priority journal; article; nicardipine; amrinone; milrinone |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 17 |
| Issue: | 3 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1999-03-01 |
| Start Page: | 991 |
| End Page: | 997 |
| Language: | English |
| PUBMED: | 10071294 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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