Short- and long-term outcomes of adult allogeneic hematopoietic stem cell transplant patients admitted to the intensive care unit in the peritransplant period Journal Article

   

Authors:	Mayer, S.; Pastores, S. M.; Riedel, E.; Maloy, M.; Jakubowski, A. A.
Article Title:	Short- and long-term outcomes of adult allogeneic hematopoietic stem cell transplant patients admitted to the intensive care unit in the peritransplant period
Abstract:	Survival of allogeneic hematopoietic stem cell transplant (aHSCT) recipients in the intensive care unit (ICU) has been poor. We retrospectively analyzed the short- and long-term outcomes of aHSCT patients admitted to the ICU over a 12-year period. Of 1235 adult patients who had aHSCT between 2002 and 2013, 161 (13%) were admitted to the ICU. The impact of clinical parameters was assessed and outcomes were compared for the periods 2002–2007 and 2008–2013. The ICU, in-hospital, 1- and 5-year survival rates were 64.6%, 46%, 33% and 20%, respectively. Mechanical ventilation and vasopressor use predicted for worse hospital- and overall survival (OS). After 2008, the requirement for mechanical ventilation and vasopressors, and the diagnosis of sepsis were reduced. While hospital mortality decreased from 69% to 44%, long-term survival (LTS) remained unchanged. Late deaths, due to causes not associated with the ICU such as relapse and graft-versus-host disease, increased. As thresholds for transplant are lowered, improvements in ICU outcomes for aHSCT recipients may be limited. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:	mortality; stem cell transplantation; intensive care; prognostic factors; allogeneic
Journal Title:	Leukemia and Lymphoma
Volume:	58
Issue:	2
ISSN:	1042-8194
Publisher:	Taylor & Francis Group
Date Published:	2017-01-01
Start Page:	382
End Page:	390
Language:	English
DOI:	10.1080/10428194.2016.1195499
PROVIDER:	scopus
PUBMED:	27347608
PMCID:	PMC5581948
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976307722&partnerID=40&md5=b03729ff016c3a6e21a8a86e7195a9d6
Notes:	Article -- Export Date: 6 December 2016 -- Source: Scopus

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