Interactions among combinations of two and three protease inhibitors against drug-susceptible and drug-resistant HIV-1 isolates Journal Article
| Authors: | Tremblay, C.; Merrill, D. P.; Chou, T. C.; Hirsch, M. S. |
| Article Title: | Interactions among combinations of two and three protease inhibitors against drug-susceptible and drug-resistant HIV-1 isolates |
| Abstract: | Protease inhibitors used in combination with reverse transcriptase inhibitors have demonstrated potent anti-HIV-1 activity in vitro as well as in vivo. We evaluated interactions among five protease inhibitors: indinavir (IDV), ritonavir (RTV), saquinavir (SQV), amprenavir (APV), and nelfinavir (NFV), when used in combinations of two and three drugs in vitro against several HIV-1 isolates, including those susceptible and resistant to various nucleoside and nonnucleoside reverse transcriptase inhibitors. Interactions ranged from synergy to slight antagonism depending on the viral isolates and the experimental conditions employed. Further clinical evaluation of protease inhibitor combinations is warranted. |
| Keywords: | controlled study; antibiotic therapy; human cell; drug potentiation; nonhuman; protease inhibitors; combination chemotherapy; drug potency; strain difference; antibiotic resistance; drug antagonism; drug therapy, combination; rna viruses; human immunodeficiency virus; antiretrovirus agent; combination therapy; virus strain; proteinase inhibitor; anti-hiv agents; drug interactions; human immunodeficiency virus 1; hiv-1; zidovudine; indinavir; rna directed dna polymerase inhibitor; minimum inhibitory concentration; ritonavir; nelfinavir; saquinavir; drug resistance, microbial; amprenavir; hiv protease inhibitors; humans; human; priority journal; article |
| Journal Title: | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 1077-9450 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1999-04-15 |
| Start Page: | 430 |
| End Page: | 436 |
| Language: | English |
| PUBMED: | 10961603 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
