Favorable interactions between enfuvirtide and 1-β-D-2, 6-diaminopurine dioxolane in vitro Journal Article

   


Authors: Tremblay, C. L.; Poulin, D. L.; Hicks, J. L.; Selliah, S.; Chamberland, A.; Giguel, F.; Kollmann, C. S.; Chou, T. C.; Dong, H.; Hirsch, M. S.
Article Title: Favorable interactions between enfuvirtide and 1-β-D-2, 6-diaminopurine dioxolane in vitro
Abstract: We evaluated the in vitro anti-human immunodeficiency virus type 1 (HIV-1) interactions between 1-β-D-2,6-diaminopurine dioxolane (DAPD) and enfuvirtide (T-20) against clinical isolates sensitive and resistant to reverse transcriptase and protease inhibitors. Interactions between T-20 and DAPD were synergistic to nearly additive, with combination index values ranging from 0.53 to 1.06 at 95% inhibitory concentrations. These studies suggest that a combination of T-20 and DAPD might be useful in the treatment of antiretroviral drug-experienced patients.
Keywords: unclassified drug; human cell; drug activity; drug potentiation; drug synergism; peptide fragments; drug sensitivity; proteinase inhibitor; anti-hiv agents; hiv infections; human immunodeficiency virus 1; drug resistance, viral; hiv-1; virus isolation; rna directed dna polymerase inhibitor; anti human immunodeficiency virus agent; hiv protease inhibitors; purine nucleosides; enfuvirtide; reverse transcriptase inhibitors; humans; human; priority journal; article; 1beta dextro 2,6 diaminopurine dioxolane; 2,6 diaminopurine derivative; dioxolanes; hiv envelope protein gp41
Journal Title: Antimicrobial Agents and Chemotherapy
Volume: 47
Issue: 11
ISSN: 0066-4804
Publisher: American Society for Microbiology  
Date Published: 2003-11-01
Start Page: 3644
End Page: 3646
Language: English
DOI: 10.1128/aac.47.11.3644-3646.2003
PUBMED: 14576137
PROVIDER: scopus
PMCID: PMC253786
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-10744220266&partnerID=40&md5=d1009dcfcb57532aba291ec254f43a08
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Huajin Dong
    33 Dong
  2. Ting-Chao Chou
    319 Chou
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