Sphincter preservation of leiomyosarcoma of the rectum and anus with local excision and brachytherapy Journal Article
| Authors: | Grann, A.; Paty, P. B.; Guillem, J. G.; Cohen, A. M.; Minsky, B. D. |
| Article Title: | Sphincter preservation of leiomyosarcoma of the rectum and anus with local excision and brachytherapy |
| Abstract: | PURPOSE: The aim of this study was to determine the outcome of patients with leiomyosarcoma of the rectum or anus treated with local excision and brachytherapy. METHODS: Eight patients with leiomyosarcoma of the rectum (7 patients) or anus (1 patient) were treated with a transanal excision followed by a temporary iridium-192 interstitial implant to 4,500 cGy. Median tumor size was 4.2 (range, 1.5-5) cm. Margins were positive in six patients, negative in one patient, and close in one patient. RESULTS: With a median follow-up of 53 months, median survival time was 53 months and the three-year actuarial survival rate was 71 percent. The cumulative incidence of failure as a component of failure for local was 25 percent (2/8), for abdominal was 0 percent (0/8), and for distant was 25 percent (2/8). Four patients eligible for functional analysis all had excellent sphincter function (1-2 bowel movements per day, no soilage). CONCLUSION: In selected patients the use of conservative surgery followed by brachytherapy is a reasonable alternative to an abdominoperineal resection. However, more experience and longer follow-up are needed before this approach can be recommended routinely. |
| Keywords: | adult; cancer survival; clinical article; aged; middle aged; excision; survival rate; treatment failure; clinical trial; combined modality therapy; follow-up studies; time factors; brachytherapy; leiomyosarcoma; rectal neoplasms; rectum tumor; iridium 192; iridium radioisotopes; rectal cancer; anal canal; preservation; rectum abdominoperineal resection; anus sphincter; anorectal disease; anus neoplasms; anus tumor; humans; human; male; female; article |
| Journal Title: | Diseases of the Colon and Rectum |
| Volume: | 42 |
| Issue: | 10 |
| ISSN: | 0012-3706 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1999-10-01 |
| Start Page: | 1296 |
| End Page: | 1299 |
| Language: | English |
| DOI: | 10.1007/bf02234218 |
| PUBMED: | 10528767 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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