Dendritic cells: Expansion and differentiation with hematopoietic growth factors Journal Article
| Author: | Young, J. W. |
| Article Title: | Dendritic cells: Expansion and differentiation with hematopoietic growth factors |
| Abstract: | Dendritic cells are critical initiators of immune responses mediated by T and B lymphocytes. Dendritic cells process antigens captured in the periphery, then emigrate to lymphoid organs. There they complete their maturation by upregulating important accessory molecules and secreting cytokines, all of which support potent stimulation of antigen-specific lymphocytes. These lymphocytes return to the periphery to complete the immune response. Investigators have discovered culture systems that use exogenous hematopoietic cytokines to support the growth, differentiation, and maturation of dendritic cells in larger numbers and greater purity than was ever before possible. This has rendered dendritic cells accessible to detailed experimental evaluations and clinical applications. Dendritic cells provide a powerful means of controlling both normal and pathologic immunity. |
| Keywords: | cell division; cell maturation; dendritic cell; cell differentiation; cell lineage; molecular cloning; antigen presentation; cytokines; dendritic cells; immune response; cytotoxic t lymphocyte; major histocompatibility complex; t lymphocyte activation; hemopoietic growth factor; receptor upregulation; langerhans cell; humans; priority journal; article |
| Journal Title: | Current Opinion in Hematology |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1065-6251 |
| Publisher: | Lippincott Williams & Wilkins, Ltd. |
| Date Published: | 1999-05-01 |
| Start Page: | 135 |
| End Page: | 144 |
| Language: | English |
| DOI: | 10.1097/00062752-199905000-00003 |
| PUBMED: | 10226733 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
