Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome Journal Article
| Authors: | Boyd, J.; Rhei, E.; Federici, M. G.; Borgen, P. I.; Watson, P.; Franklin, B.; Karr, B.; Lynch, J.; Lemon, S. J.; Lynch, H. T. |
| Article Title: | Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome |
| Abstract: | A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic reduction to homozygosity for the MLH1 mutation, and microsatellite instability was evident in the breast tumor. We conclude that hereditary male breast cancer can occur as an integral tumor in the HNPCC syndrome. |
| Keywords: | human tissue; aged; gene mutation; case report; polymerase chain reaction; colorectal cancer; breast cancer; alleles; microsatellite dna; pedigree; germ line; homozygosity; mismatch repair; microsatellite instability; dna primers; loss of heterozygosity; hnpcc; colorectal neoplasms, hereditary nonpolyposis; germ-line mutation; hereditary; male breast cancer; male breast; breast neoplasms, male; carcinoma, ductal, breast; microsatellite repeats; mlh1; gene segregation; humans; human; male; priority journal; article |
| Journal Title: | Breast Cancer Research and Treatment |
| Volume: | 53 |
| Issue: | 1 |
| ISSN: | 0167-6806 |
| Publisher: | Springer |
| Date Published: | 1999-01-01 |
| Start Page: | 87 |
| End Page: | 91 |
| Language: | English |
| DOI: | 10.1023/a:1006030116357 |
| PUBMED: | 10206076 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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