An (225)Ac/(213)Bi generator system for therapeutic clinical applications: Construction and operation Journal Article
| Authors: | McDevitt, M. R.; Finn, R. D.; Sgouros, G.; Ma, D.; Scheinberg, D. A. |
| Article Title: | An (225)Ac/(213)Bi generator system for therapeutic clinical applications: Construction and operation |
| Abstract: | A method for construction and operation of an 225Ac/213Bi generator capable of producing 25-100 mCi of 213Bi suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described 213Bi generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclidic purity are addressed. |
| Keywords: | radiation dose; methodology; radiotherapy; immunology; isotope labeling; instrumentation; radioactivity; nuclear medicine; radioactive tracers; antibodies; radioisotope; radioimmunotherapy; radioisotopes; radiation protection; antibody labeling; alpha radiation; radiation damage; bismuth; alpha particles; 225ac; actinium; radionuclide generators; priority journal; article; 213bi; 213bi generator; alpha-particle emitting radionuclide; radiation chemistry |
| Journal Title: | Applied Radiation and Isotopes |
| Volume: | 50 |
| Issue: | 5 |
| ISSN: | 0969-8043 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1999-05-01 |
| Start Page: | 895 |
| End Page: | 904 |
| Language: | English |
| DOI: | 10.1016/s0969-8043(98)00151-1 |
| PUBMED: | 10214708 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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146Sgouros -
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Finn -
144Mcdevitt -
21
Ma -
499Scheinberg
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