Rapid preparation of short-lived alpha particle emitting radioimmunopharmaceuticals Journal Article

  


Authors: Ma, D.; McDevitt, M. R.; Finn, R. D.; Scheinberg, D. A.
Article Title: Rapid preparation of short-lived alpha particle emitting radioimmunopharmaceuticals
Abstract: Alpha emitting radionuclides are of considerable interest for targeted radioimmunotherapy. Generator supplied 213Bi emitting 8.5 MeV alpha particles with a 45.6 min half-life has been conjugated to a monoclonal antibody (HuM 195-CHX-A-DTPA) for targeted therapy of leukemia in a clinical trial. The clinical dose preparation of pharmaceutical formulation by a pair of skilled radiochemists took 25 min, which corresponds, to an overall decay loss of 30% of the initial 213Bi activity eluted from the generator. In order to allow more widespread and practical clinical use of targeted 213Bi alpha particle therapy, we developed a new procedure that is simpler, more rapid and adaptable to a hospital pharmacy. The new 10 min process includes a tandem elution and labeling, and an anion exchange column purification method that can be reproducibly used. © 2001 Elsevier Science Ltd. All rights reserved.
Keywords: drug targeting; radiopharmaceuticals; reproducibility; drug synthesis; time; monoclonal antibodies; monoclonal antibody; antibodies, monoclonal; radioactivity; radiopharmaceutical agent; drug labeling; radioisotope; drug half life; radioimmunotherapy; radioisotopes; technique; radioisotope decay; drug conjugation; clinical trials; half-life; drug use; drug formulation; drug purification; alpha radiation; immunoconjugates; bismuth; alpha particles; drug products; bismuth 213; purification; leukemia, myelocytic, acute; anion exchange chromatography; chromatography, ion exchange; negative ions; generator; humans; priority journal; article; 213bi; alpha emitting radionuclide; anion exchange purification
Journal Title: Applied Radiation and Isotopes
Volume: 55
Issue: 4
ISSN: 0969-8043
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 2001-10-01
Start Page: 463
End Page: 470
Language: English
DOI: 10.1016/s0969-8043(01)00048-3
PUBMED: 11545498
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034922185&partnerID=40&md5=6700e1c25098c39bea1d8bad8d34f26e
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Ronald D Finn
    279 Finn
  2. Michael R Mcdevitt
    144 Mcdevitt
  3. Dangshe Ma
    21 Ma
  4. David Scheinberg
    499 Scheinberg
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