Surgical salvage of recurrent rectal carcinoma after curative resection: A 10-year experience Journal Article
| Authors: | Salo, J. C.; Paty, P. B.; Guillem, J.; Minsky, B. D.; Harrison, L. B.; Cohen, A. M. |
| Article Title: | Surgical salvage of recurrent rectal carcinoma after curative resection: A 10-year experience |
| Abstract: | Background: Local recurrence after resection of rectal carcinoma is a difficult clinical problem that adversely affects both survival and quality of life. Surgical resection is possible for a subset of patients with localized recurrences. We reviewed our experience with surgical salvage of recurrent rectal carcinoma, to determine predictors of resectability and postsalvage survival rates. Methods: A 10-year, retrospective analysis of 131 patients who underwent exploration with curative intent for local recurrence after radical resection of rectal carcinomas in a single referral institution, was performed. Preoperative and pathological factors were examined for their ability to predict postresection survival rates and resectability. Results: The overall 5-year survival rate for patients who underwent exploration with curative intent was 24%. Resection of recurrent disease was possible for 103 of 131 (79%) patients, with a resulting 5-year survival rate of 31%. Patients who were treated initially with abdomino- perineal resection (n = 35) presented later and were less likely to have resectable tumors than were those treated initially with some form of sphincter-preserving resection (n = 96). Among patients who could undergo resection, normal carcinoembryonic antigen levels and recurrent disease limited to the bowel wall were both favorable features. Conclusions: Surgical salvage of local recurrence after radical resection of rectal carcinoma can be performed safely and can result in substantial long-term survival benefits for selected patients. |
| Keywords: | survival; adult; cancer survival; controlled study; treatment outcome; cancer surgery; major clinical study; clinical feature; salvage therapy; fluorouracil; disease marker; cancer adjuvant therapy; cancer radiotherapy; cancer staging; recurrent cancer; cancer palliative therapy; treatment indication; carcinoembryonic antigen; prediction; medical record; surgery; rectum carcinoma; rectal cancer; rectum abdominoperineal resection; local recurrence; prognosis; human; male; female; article |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 6 |
| Issue: | 2 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 1999-03-01 |
| Start Page: | 171 |
| End Page: | 177 |
| Language: | English |
| PUBMED: | 10082043 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s10434-999-0171-8 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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