Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders Journal Article
| Authors: | Saiz, A.; Graus, F.; Dalmau, J.; Pifarré, A.; Marín, C.; Tolosa, E. |
| Article Title: | Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders |
| Abstract: | The detection of 14-3-3 protein in cerebrospinal fluid by immunoblotting is useful for the diagnosis of Creutzfeldt-Jakob disease (CJD). We found 14- 3-3 protein in 10 of 80 (12.5%) patients with paraneoplastic neurological disorders (PNDs), whose presenting symptoms may mimic those of CJD. In 47 of 48 CJD patients, the 14-3-3 protein was detected as a single band, and it was detected as a double band in 1 patient. The double-band pattern was observed in 9 of the 10 14-3-3 protein-positive patients with PNDs. The 14-3-3 protein assay may be positive in PND patients, but the immunoblotting pattern distinguishes most PND samples from those of CJD. |
| Keywords: | adult; controlled study; aged; middle aged; major clinical study; proteins; diagnosis, differential; brain; predictive value of tests; immunoblotting; cerebrospinal fluid analysis; encephalitis; paraneoplastic syndrome; protein determination; brain protein; 14-3-3 proteins; paraneoplastic cerebellar degeneration; creutzfeldt jakob disease; tyrosine 3-monooxygenase; paraneoplastic syndromes, nervous system; limbic encephalitis; humans; human; male; female; priority journal; article; creutzfeldt-jakob syndrome |
| Journal Title: | Annals of Neurology |
| Volume: | 46 |
| Issue: | 5 |
| ISSN: | 0364-5134 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1999-11-01 |
| Start Page: | 774 |
| End Page: | 777 |
| Language: | English |
| DOI: | 10.1002/1531-8249(199911)46:5<774::aid-ana14>3.0.co;2-n |
| PUBMED: | 10970247 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
