Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders Journal Article


Authors: Saiz, A.; Graus, F.; Dalmau, J.; Pifarré, A.; Marín, C.; Tolosa, E.
Article Title: Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders
Abstract: The detection of 14-3-3 protein in cerebrospinal fluid by immunoblotting is useful for the diagnosis of Creutzfeldt-Jakob disease (CJD). We found 14- 3-3 protein in 10 of 80 (12.5%) patients with paraneoplastic neurological disorders (PNDs), whose presenting symptoms may mimic those of CJD. In 47 of 48 CJD patients, the 14-3-3 protein was detected as a single band, and it was detected as a double band in 1 patient. The double-band pattern was observed in 9 of the 10 14-3-3 protein-positive patients with PNDs. The 14-3-3 protein assay may be positive in PND patients, but the immunoblotting pattern distinguishes most PND samples from those of CJD.
Keywords: adult; controlled study; aged; middle aged; major clinical study; proteins; diagnosis, differential; brain; predictive value of tests; immunoblotting; cerebrospinal fluid analysis; encephalitis; paraneoplastic syndrome; protein determination; brain protein; 14-3-3 proteins; paraneoplastic cerebellar degeneration; creutzfeldt jakob disease; tyrosine 3-monooxygenase; paraneoplastic syndromes, nervous system; limbic encephalitis; humans; human; male; female; priority journal; article; creutzfeldt-jakob syndrome
Journal Title: Annals of Neurology
Volume: 46
Issue: 5
ISSN: 0364-5134
Publisher: Wiley Blackwell  
Date Published: 1999-11-01
Start Page: 774
End Page: 777
Language: English
DOI: 10.1002/1531-8249(199911)46:5<774::aid-ana14>3.0.co;2-n
PUBMED: 10970247
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 16 August 2016 -- Source: Scopus
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MSK Authors
  1. Josep O Dalmau
    92 Dalmau