Retrospective outcome data for hematopoietic stem cell transplantation in patients with concurrent coronary artery disease Journal Article

  


Authors: Stillwell, E. E.; Wessler, J. D.; Rebolledo, B. J.; Steingart, R. M.; Petrlik, E. L.; Jakubowski, A. A.; Schaffer, W. L.
Article Title: Retrospective outcome data for hematopoietic stem cell transplantation in patients with concurrent coronary artery disease
Abstract: Hematopoietic stem cell transplantation (HSCT) represents an extended period of physiologic stress. It is unknown whether patients with pre-existing coronary artery disease (CAD) may be poor transplant candidates. There are no data analyzing the risk of transplantation in this population. Sixty-nine patients with CAD who underwent 72 transplantations, autologous and allogeneic, were identified retrospectively. Fifty-five percent of these patients had prior percutaneous coronary intervention, 42% had verifiable history of myocardial infarction, and 23% had prior coronary artery bypass grafting. Outcomes were compared to 1109 patients without established CAD who underwent 1183 transplants during the same time period. Cancer diagnoses in the 2 groups were similar, predominantly lymphoma, multiple myeloma, and leukemia. There was no significant difference between the CAD group and the control group with respect to type of transplant (autologous 68% versus 64%, P = 612, myeloablative 86% versus 85%, P = 867). Treatment-related mortality was no different in the CAD group versus the control group (5.6% versus 4.9%, P = 777), nor were there differences in mortality at 1 year (15.3% versus 16.6%, P = 871), urgent intensive care unit admission (11.1% versus 9.9%, P = 686), or length of stay (25.5 days versus 28.4 days, P = 195). These findings suggest many patients with underlying coronary artery disease may be safely managed through hematopoietic stem cell transplantation. © 2011 American Society for Blood and Marrow Transplantation.
Keywords: adult; controlled study; treatment outcome; middle aged; leukemia; retrospective studies; major clinical study; mortality; outcome assessment; cancer diagnosis; multiple myeloma; hematopoietic stem cell transplantation; retrospective study; intensive care; coronary artery bypass; length of stay; myeloablative conditioning; heart infarction; lymphoma; hospital admission; bypass surgery; coronary artery disease; autologous hematopoietic stem cell transplantation; percutaneous coronary intervention
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 17
Issue: 8
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2011-08-01
Start Page: 1182
End Page: 1186
Language: English
DOI: 10.1016/j.bbmt.2010.12.698
PROVIDER: scopus
PUBMED: 21182974
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79960243435&partnerID=40&md5=bd094ea43e9950a4a902205aefce296e
Notes: --- - "Export Date: 17 August 2011" - "CODEN: BBMTF" - "Source: Scopus"
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MSK Authors
  1. Wendy Lynn Schaffer
    25 Schaffer
  2. Richard M Steingart
    174 Steingart
  3. Ann Jakubowski
    455 Jakubowski
  4. Elizabeth Stillwell
    7 Stillwell
  5. Erica Luisa Petrlik
    10 Petrlik
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