T cell receptor signalling in the control of regulatory T cell differentiation and function Journal Article

   

Authors:	Li, M. O.; Rudensky, A. Y.
Article Title:	T cell receptor signalling in the control of regulatory T cell differentiation and function
Abstract:	Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the control of self tolerance and inflammatory responses. Recent studies have revealed a discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation, maintenance and function and that affects gene expression, metabolism, cell adhesion and migration of these cells. Here, we discuss the emerging understanding of TCR-guided differentiation of TReg cells in the context of their function in health and disease. © 2016 Macmillan Publishers Limited. All rights reserved.
Journal Title:	Nature Reviews Immunology
Volume:	16
Issue:	4
ISSN:	1474-1733
Publisher:	Nature Publishing Group
Date Published:	2016-04-01
Start Page:	220
End Page:	233
Language:	English
DOI:	10.1038/nri.2016.26
PROVIDER:	scopus
PUBMED:	27026074
PMCID:	PMC4968889
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978634373&partnerID=40&md5=5fdcc531ae42a03a451ec148614580fe
Notes:	Review -- Export Date: 2 August 2016 -- Source: Scopus

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