PET-avid hepatocellular adenomas: Incidental findings associated with HNF1-alpha mutated lesions Journal Article
| Authors: | Lee, S. Y.; Kingham, T. P.; LaGratta, M. D.; Jessurun, J.; Cherqui, D.; Jarnagin, W. R.; Kluger, M. D. |
| Article Title: | PET-avid hepatocellular adenomas: Incidental findings associated with HNF1-alpha mutated lesions |
| Abstract: | Background: Hepatocellular adenoma (HCA) is the second most common benign liver neoplasm and occurs predominantly in women in their reproductive years. Positron emission tomography (PET) using [18F] fluorodeoxyglucose (FDG) is commonly used in cancer staging, surveillance and evaluation of treatment response. PET-avid HCA are rare and can be falsely interpreted as malignancies. Methods A retrospective review of four institutions' database was performed to identify the PET-avid HCAs with clinico-pathological correlation. Results: Nine patients with histological proven PET-avid HCA was identified. Eight out of 9 patients were female with a median age at diagnosis of 44 years. All patients' tumors with available histological subtyping (8/8) were HNF1-Q mutated and had no inflammatory changes; 6 out the 9 lesions had prominent (>50%) steatotic changes. Conclusion: Hepatocellular adenomas, specifically the HNF1-ɑ subtype, can cause false-positive PET findings when seeking to identify malignancy. Concomitantly, PET-CT may have the potential to identify the HCA histopathologic variant with the lowest malignant and hemorrhagic potential. © 2015 International Hepato-Pancreato-Biliary Association Inc. |
| Journal Title: | HPB |
| Volume: | 18 |
| Issue: | 1 |
| ISSN: | 1365-182X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2016-01-01 |
| Start Page: | 41 |
| End Page: | 48 |
| Language: | English |
| DOI: | 10.1016/j.hpb.2015.07.001 |
| PROVIDER: | scopus |
| PMCID: | PMC4750225 |
| PUBMED: | 26776850 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2016 -- Source: Scopus |
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