The immune microenvironment in hodgkin lymphoma: T cells, B cells, and immune checkpoints Journal Article
| Authors: | Vardhana, S.; Younes, A. |
| Article Title: | The immune microenvironment in hodgkin lymphoma: T cells, B cells, and immune checkpoints |
| Abstract: | Classical Hodgkin lymphoma is curable in the majority of cases with chemotherapy and/or radiation. However, 15-20% of patients ultimately relapse and succumb to their disease. Pathologically, classical Hodgkin lymphoma is characterized by rare tumor-initiating Reed-Sternberg cells surrounded by a dense immune microenvironment. However, the role of the immune microenvironment, particularly T and B cells, in either promoting or restricting Classical Hodgkin lymphoma growth remains undefined. Recent dramatic clinical responses seen using monoclonal antibodies against PD-1, a cell surface receptor whose primary function is to restrict T cell activation, have reignited questions regarding the function of the adaptive immune system in classical Hodgkin lymphoma. This review summarizes what is known regarding T cells, B cells, and immune checkpoints in classical Hodgkin lymphoma. © 2016 Ferrata Storti Foundation. |
| Journal Title: | Haematologica |
| Volume: | 101 |
| Issue: | 7 |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Date Published: | 2016-07-01 |
| Start Page: | 794 |
| End Page: | 802 |
| Language: | English |
| DOI: | 10.3324/haematol.2015.132761 |
| PROVIDER: | scopus |
| PUBMED: | 27365459 |
| PMCID: | PMC5004458 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2016 -- Source: Scopus |
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