Clinicopathologic features of colorectal carcinoma in HIV-positive patients Journal Article
| Authors: | Sigel, C.; Cavalcanti, M. S.; Daniel, T.; Vakiani, E.; Shia, J.; Sigel, K. |
| Article Title: | Clinicopathologic features of colorectal carcinoma in HIV-positive patients |
| Abstract: | Background: Emerging evidence suggests differences in colorectal cancer in HIV-infected patients (HIV+) compared with HIV- patients. Microsatellite instability (MSI), occurring in a subset of colorectal cancer, is present at a higher rate in certain cancers in HIV+ patients. Colorectal cancer with MSI share some characteristics with those reported for HIV+ colorectal cancer. On this premise, we studied clinical and pathologic features of HIV+ colorectal cancer and evaluated for MSI using matched HIV- colorectal cancer controls. Methods: Two nested, matched cohorts were identified from a hospital-based cohort of colorectal cancer patients. HIV+ colorectal cancers were identified and random control patients were matched for selected characteristics. Mismatch repair protein (MMR) IHC was performed as the detection method for MSI. Variables were compared between cases and controls using fixedeffects logit modeling to account for matching. Results: We included 184 colorectal cancer samples (38 HIV+, 146 HIV- control). Median patient age at colorectal cancer onset was 55. When compared with HIV- colorectal cancer, HIV+ patients were more likely to have smoked (P = 0.001), have right-sided colorectal cancer (37% vs. 14%; P = 0.003), and tumor-infiltrating lymphocytes (TIL) above 50/10 high-power fields (21% vs. 7%). Therewas no difference inMMRprotein expression (P= 0.6). HIV+ colorectal cancer patients had reduced overall survival (P = 0.02) but no difference in progression-free survival. Conclusions: HIV+ patients developed colorectal cancer at a lower median age than population estimates, had a higher frequency of right-sided disease, and increased TILs, suggesting potential biologic differences compared with uninfected patients. Impact: Clinicopathologic differences in colorectal cancer of HIV+ persons may have implications for tumor pathogenesis. © 2016 American Association for Cancer Research. |
| Journal Title: | Cancer Epidemiology Biomarkers and Prevention |
| Volume: | 25 |
| Issue: | 7 |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2016-07-01 |
| Start Page: | 1098 |
| End Page: | 1104 |
| Language: | English |
| DOI: | 10.1158/1055-9965.epi-15-1179 |
| PROVIDER: | scopus |
| PMCID: | PMC4942127 |
| PUBMED: | 27197294 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
719Shia -
264Vakiani -
115Sigel -
16Cavalcanti -
8Daniel
Related MSK Work