A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL) Journal Article
| Authors: | Mavrakis, K. J.; Van Der Meulen, J.; Wolfe, A. L.; Liu, X.; Mets, E.; Taghon, T.; Khan, A. A.; Setty, M.; Rondou, P.; Vandenberghe, P.; Delabesse, E.; Benoit, Y.; Socci, N.; Leslie, C. S.; Van Vlierberghe, P.; Speleman, F.; Wendel, H. G. |
| Article Title: | A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL) |
| Abstract: | The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene interactions in this cancer. © 2011 Nature America, Inc. All rights reserved. |
| Keywords: | controlled study; protein expression; nonhuman; conference paper; mouse; animal tissue; microrna; embryo; animal experiment; animal model; tumor suppressor gene; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; t cell leukemia; cooperation; ikaros transcription factor; hepatocyte nuclear factor 1 |
| Journal Title: | Nature Genetics |
| Volume: | 43 |
| Issue: | 7 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-07-01 |
| Start Page: | 673 |
| End Page: | 678 |
| Language: | English |
| DOI: | 10.1038/ng.858 |
| PROVIDER: | scopus |
| PUBMED: | 21642990 |
| PMCID: | PMC4121855 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 August 2011" - "CODEN: NGENE" - "Source: Scopus" |
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