Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck Journal Article
| Author: | Mandapathil, M. |
| Article Title: | Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck |
| Abstract: | This review article describes the potential role of ectonucleotidase activity, adenosine metabolism, and the adenosinergic signaling pathway in the suppression of the host immune system in patients with head and neck cancer. Identifying such mechanisms leads to a better understanding of immunosuppressive mechanisms in this patient population. Further, potential targets for immunotherapy in an adjuvant approach to treating squamous cell carcinoma of the head and neck in the future might be identified and improve the prognosis of these patients. |
| Keywords: | immunotherapy; head and neck cancer; adenosine; receptor; regulatory t cells; expression; signaling pathways; peripheral-blood; regulatory t-cells; generation; responses; cancer-cells; tumor microenvironment; immune suppression; extracellular atp |
| Journal Title: | HNO |
| Volume: | 64 |
| Issue: | 5 |
| ISSN: | 0017-6192 |
| Publisher: | Springer |
| Date Published: | 2016-05-01 |
| Start Page: | 303 |
| End Page: | 309 |
| Language: | English |
| ACCESSION: | WOS:000377442900005 |
| DOI: | 10.1007/s00106-016-0137-7 |
| PROVIDER: | wos |
| PUBMED: | 27052632 |
| Notes: | Article -- Source: Wos |
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