Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities Journal Article


Authors: Bain, C. C.; Hawley, C. A.; Garner, H.; Scott, C. L.; Schridde, A.; Steers, N. J.; Mack, M.; Joshi, A.; Guilliams, M.; Mowat, A. M. I.; Geissmann, F.; Jenkins, S. J.
Article Title: Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
Abstract: Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the composition, developmental origin and mechanisms governing the maintenance of this compartment are controversial. Here we show resident F4/80 hi GATA6 + macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at least 4 months in mice. However, Ly6C + monocytes constitutively enter the peritoneal cavity in a CCR2-dependent manner, where they mature into short-lived F4/80lo MHCII+ cells that act, in part, as precursors of F4/80 hi GATA6 + macrophages. Notably, monocyte-derived F4/80 hi macrophages eventually displace the embryonic population with age in a process that is highly gender dependent and not due to proliferative exhaustion of the incumbent embryonic population, despite the greater proliferative activity of newly recruited cells. Furthermore, although monocyte-derived cells acquire key characteristics of the embryonic population, expression of Tim4 was impaired, leading to cumulative changes in the population with age.
Keywords: mus
Journal Title: Nature Communications
Volume: 7
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2016-06-13
Start Page: 11852
Language: English
DOI: 10.1038/ncomms11852
PROVIDER: scopus
PMCID: PMC4910019
PUBMED: 27292029
DOI/URL:
Notes: Article -- Export Date: 1 July 2016 -- Source: Scopus
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