New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches Journal Article
| Authors: | Obar, J. J.; Hohl, T. M.; Cramer, R. A. |
| Article Title: | New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches |
| Abstract: | Invasive aspergillosis (IA) remains a devastating disease in immune compromised patients despite significant advances in our understanding of fungal virulence and host defense mechanisms. In this review, we summarize important research advances in the fight against IA with particular focus on early events in the interactions between Aspergillus fumigatus and the host that occur in the respiratory tract. Advances in understanding mechanisms of immune effector cell recruitment, antifungal effector mechanisms, and how the dynamic host-fungal interaction alters the local microenvironment to effect outcomes are highlighted. These advances illustrate exciting new therapeutic opportunities, but also emphasize the importance of understanding each unique fungus-host interaction for improving patient outcomes. © 2016 Elsevier Ltd. |
| Keywords: | protein expression; review; nonhuman; interleukin 1beta; protein binding; neutrophil; innate immunity; host resistance; cytokine release; cxcl2 chemokine; leukocyte; dectin 1; myeloid differentiation factor 88; aspergillus fumigatus; fungus hyphae; lung aspergillosis; fungus growth; cxcl1 chemokine; host pathogen interaction; personalized medicine; antifungal activity; invasive aspergillosis; interleukin 1beta converting enzyme; toll like receptor 9; microbial diversity; dectin 2; epithelial derived neutrophil activating factor 78; chemokine receptor cxcr2; phagocytes; fungal virulence; pentraxin 3; fungus immunity; human; priority journal; antifungal effector |
| Journal Title: | Cytokine |
| Volume: | 84 |
| ISSN: | 1043-4666 |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 2016-08-01 |
| Start Page: | 63 |
| End Page: | 73 |
| Language: | English |
| DOI: | 10.1016/j.cyto.2016.05.015 |
| PROVIDER: | scopus |
| PMCID: | PMC4904826 |
| PUBMED: | 27253487 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2016 -- Source: Scopus |
