Epithelial responses to fungal pathogens Review
| Authors: | Mills, K. A. M.; Aufiero, M. A.; Hohl, T. M. |
| Review Title: | Epithelial responses to fungal pathogens |
| Abstract: | Epithelial cells orchestrate immune responses against fungal pathogens. This review highlights advances in integrating epithelial cells in immune responses against inhaled molds and dimorphic fungi, and against Candida species that colonize mucosal surfaces. In the lung, epithelial cells respond to interleukin-1 (IL-1) and interferon signaling to regulate effector cell influx and fungal killing. In the alimentary and vulvovaginal tracts, epithelial cells modulate fungal commensalism, invasive growth, and local immune tone, in part by responding to damage caused by candidalysin, a C. albicans peptide toxin, and through IL-17-dependent release of antimicrobial peptides that contribute to Candida colonization resistance. Understanding fungal–epithelial interactions in mammalian models of disease is critical to predict vulnerabilities and to identify opportunities for immune-based strategies to treat fungal infections. © 2024 Elsevier Ltd |
| Keywords: | human cell; review; nonhuman; immune response; drug combination; epithelium cell; effector cell; interleukin 17; epithelium; drug therapy; candida albicans; pharmacology; interleukin 1; drug comparison; polypeptide antibiotic agent; human; female |
| Journal Title: | Current Opinion in Microbiology |
| Volume: | 80 |
| ISSN: | 1369-5274 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-07-31 |
| Start Page: | 102508 |
| Language: | English |
| DOI: | 10.1016/j.mib.2024.102508 |
| PROVIDER: | scopus |
| PUBMED: | 38986398 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Group (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Tobias Hohl -- Source: Scopus |
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