Integrated genomics for pinpointing survival loci within arm-level somatic copy number alterations Journal Article

   

Authors:	Roy, D. M.; Walsh, L. A.; Desrichard, A.; Huse, J. T.; Wu, W.; Gao, J.; Bose, P.; Lee, W.; Chan, T. A.
Article Title:	Integrated genomics for pinpointing survival loci within arm-level somatic copy number alterations
Abstract:	The identification of driver loci underlying arm-level somatic copy number alterations (SCNAs) in cancer has remained challenging and incomplete. Here, we assess the relative impact and present a detailed landscape of arm-level SCNAs in 10,985 patient samples across 33 cancer types from The Cancer Genome Atlas (TCGA). Furthermore, using chromosome 9p loss in lower grade glioma (LGG) as a model, we employ a unique multi-tiered genomic dissection strategy using 540 patients from three independent LGG datasets to identify genetic loci that govern tumor aggressiveness and poor survival. This comprehensive approach uncovered several 9p loss-specific prognostic markers, validated existing ones, and redefined the impact of CDKN2A loss in LGG. © 2016 Elsevier Inc.
Journal Title:	Cancer Cell
Volume:	29
Issue:	5
ISSN:	1535-6108
Publisher:	Cell Press
Date Published:	2016-05-09
Start Page:	737
End Page:	750
Language:	English
DOI:	10.1016/j.ccell.2016.03.025
PROVIDER:	scopus
PMCID:	PMC4864611
PUBMED:	27165745
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975261030&partnerID=40&md5=d2ccd852cc1898e4b599a09c3c6c36b9
Notes:	Article -- Export Date: 1 July 2016 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/94548