fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: A comparison with Broca's area Journal Article

   

Authors:	Dong, J. W.; Brennan, N. M. P.; Izzo, G.; Peck, K. K.; Holodny, A. I.
Article Title:	fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: A comparison with Broca's area
Abstract:	Introduction Functional MRI (fMRI) can assess language lateralization in brain tumor patients; however, this can be limited if the primary language area-Broca's area (BA)-is affected by the tumor. We hypothesized that the middle frontal gyrus (MFG) can be used as a clinical indicator of hemispheric dominance for language during presurgical workup. Methods Fifty-two right-handed subjects with solitary left-hemispheric primary brain tumors were retrospectively studied. Subjects performed a verbal fluency task during fMRI. The MFG was compared to BA for fMRI voxel activation, language laterality index (LI), and the effect of tumor grade on the LI. Results Language fMRI (verbal fluency) activated more voxels in MFG than in BA (MFG = 315, BA = 216, p < 0.001). Voxel activations in the left-hemispheric MFG and BA were positively correlated (r = 0.69, p < 0.001). Mean LI in the MFG was comparable to that in BA (MFG = 0.48, BA = 0.39, p = 0.06). LIs in MFG and BA were positively correlated (r = 0.62, p < 0.001). Subjects with high-grade tumors demonstrate lower language lateralization than those with low-grade tumors in both BA and MFG (p = 0.02, p = 0.02, respectively). Conclusion MFG is comparable to BA in its ability to indicate hemispheric dominance for language using a measure of verbal fluency and may be an adjunct measure in the clinical determination of language laterality for presurgical planning.
Keywords:	hemispheric dominance; motor cortex; functional imaging; functional mri; generation; temporal-lobe epilepsy; stimulation; lateralization; working-memory; wada test; language lateralization; middle; brainmapping; frontal gyrus; clinical fmri; reorganization
Journal Title:	Neuroradiology
Volume:	58
Issue:	5
ISSN:	0028-3940
Publisher:	Springer
Date Published:	2016-05-01
Start Page:	513
End Page:	520
Language:	English
ACCESSION:	WOS:000374972100010
DOI:	10.1007/s00234-016-1655-4
PROVIDER:	wos
PUBMED:	26847705
PMCID:	PMC4990063
Notes:	Article -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/94166