Infiltration of the basal ganglia by brain tumors is associated with the development of co-dominant language function on fMRI Journal Article

   

Authors:	Shaw, K.; Brennan, N.; Woo, K.; Zhang, Z.; Young, R.; Peck, K.; Holodny, A.
Article Title:	Infiltration of the basal ganglia by brain tumors is associated with the development of co-dominant language function on fMRI
Abstract:	Studies have shown that some patients with left-hemispheric brain tumors have an increased propensity for developing right-sided language support. However, the precise trigger for establishing co-dominant language function in brain tumor patients remains unknown. We analyzed the MR scans of patients with left-hemispheric tumors and either co-dominant (n = 35) or left-hemisphere dominant (n = 35) language function on fMRI to investigate anatomical factors influencing hemispheric language dominance. Of eleven neuroanatomical areas evaluated for tumor involvement, the basal ganglia was significantly correlated with co-dominant language function (p < 0.001). Moreover, among patients whose tumors invaded the basal ganglia, those with language co-dominance performed significantly better on the Boston Naming Test, a clinical measure of aphasia, compared to their left-lateralized counterparts (56.5 versus 36.5, p = 0.025). While further studies are needed to elucidate the role of the basal ganglia in establishing co-dominance, our results suggest that reactive co-dominance may afford a behavioral advantage to patients with left-hemispheric tumors. © 2016 Elsevier Inc.
Keywords:	functional magnetic resonance imaging; language laterality; brain tumors; basal ganglia; boston naming test; co-dominance
Journal Title:	Brain and Language
Volume:	155-156
ISSN:	0093-934X
Publisher:	Elsevier Inc.
Date Published:	2016-04-01
Start Page:	44
End Page:	48
Language:	English
DOI:	10.1016/j.bandl.2016.04.002
PROVIDER:	scopus
PUBMED:	27108246
PMCID:	PMC4868667
DOI/URL:	https://www.scopus.com/inward/record.url?eid=2-s2.0-84963971847&partnerID=40&md5=a40a0305ee412b2696caf42cea67c2d4
Notes:	Article -- Export Date: 2 May 2016 -- Source: Scopus

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