Texture analysis of non-contrast-enhanced computed tomography for assessing angiogenesis and survival of soft tissue sarcoma Journal Article
| Authors: | Hayano, K.; Tian, F.; Kambadakone, A. R.; Yoon, S. S.; Duda, D. G.; Ganeshan, B.; Sahani, D. V. |
| Article Title: | Texture analysis of non-contrast-enhanced computed tomography for assessing angiogenesis and survival of soft tissue sarcoma |
| Abstract: | OBJECTIVE: To evaluate the role of computed tomographic (CT) texture analysis in assessing tumor angiogenesis and survival of soft tissue sarcoma (STS). METHODS: In 20 patients with STSs, tumor texture parameters, which were measured on pretherapeutic CT using CT texture analysis software with the spatial scale filter extracting fine to coarse texture, were compared with microvessel density, plasma vascular endothelial growth factor (VEGF), soluble VEGF receptor-1, and overall survival (OS). RESULTS: Mean of positive pixels (MPP) showed a positive correlation with microvessel density (P = 0.02). Entropy at medium texture scales (spatial scale filter = 3, 4, 5) showed positive correlations with VEGF (P = 0.03, P = 0.009, and P = 0.02, respectively), and entropy without filtration showed a positive correlation with soluble VEGF receptor-1 (P = 0.02). In the univariate analysis, kurtosis at a medium texture scale and MPP showed significant correlations with OS (P = 0.04 and P = 0.007), and multivariate analysis demonstrated that MPP was an independent prognostic factor (P = 0.01). CONCLUSION: Texture parameters are associated with tumor angiogenesis and OS in STS. |
| Keywords: | survival; adult; aged; middle aged; survival analysis; vascular endothelial growth factor a; clinical trial; adjuvant therapy; neoadjuvant therapy; follow up; follow-up studies; biomarkers; biological marker; phase 2 clinical trial; observer variation; neovascularization, pathologic; sarcoma; blood; vasculotropin a; radiography; neovascularization (pathology); multidetector computed tomography; humans; human; male; female |
| Journal Title: | Journal of Computer Assisted Tomography |
| Volume: | 39 |
| Issue: | 4 |
| ISSN: | 0363-8715 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2015-07-01 |
| Start Page: | 607 |
| End Page: | 612 |
| Language: | English |
| DOI: | 10.1097/rct.0000000000000239 |
| PUBMED: | 25793653 |
| PROVIDER: | scopus |
| PMCID: | PMC4504795 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 June 2016 -- Source: Scopus |
