Phytoestrogen consumption and endometrial cancer risk: A population-based case-control study in New Jersey Journal Article


Authors: Bandera, E. V.; Williams, M. G.; Sima, C.; Bayuga, S.; Pulick, K.; Wilcox, H.; Soslow, R.; Zauber, A. G.; Olson, S. H.
Article Title: Phytoestrogen consumption and endometrial cancer risk: A population-based case-control study in New Jersey
Abstract: Phytoestrogens have been shown to exert anti-estrogenic and estrogenic effects in some tissues, including the breast. However, only a few studies have evaluated their role in endometrial cancer risk. We evaluated this association in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed an interview, including a food frequency questionnaire with supplemental questions for phytoestrogen foods. Risk estimates were derived using an unconditional logistic regression, adjusting for major risk factors for endometrial cancer. There was some suggestion of a decreased risk with quercetin intake (OR: 0.65; 95% CI: 0.41-1.01 for the highest compared to the lowest quartile; p for trend: 0.02). We found a limited evidence of an association with any of the lignans evaluated, total lignans, coumestrol, individual isoflavones, total isoflavones, or total phytoestrogens. However, there was some suggestion of an inverse association with total isoflavone intake limited to lean women (BMI <25; OR for the highest tertile: 0.50; 95% CI: 0.25-0.98) and those with a waist-to-hip ratio ≤0.85 (OR: 0.59; 95% CI: 0.33-1.05). There was no evidence of effect modification by HRT use. This study suggests a reduction in endometrial cancer risk with quercetin intake and with isoflavone intake in lean women. © 2009 Springer Science+Business Media B.V.
Keywords: adult; controlled study; aged; middle aged; major clinical study; case control study; case-control studies; cancer risk; united states; endometrial neoplasms; endometrium cancer; estrogen therapy; risk factors; risk factor; risk assessment; diet; isoflavones; lignans; phytoestrogens; quercetin; coumestrol derivative; isoflavone derivative; lignan derivative; phytoestrogen; body mass; correlation analysis; food composition; food frequency questionnaire; population research; waist hip ratio; body mass index; coumestrol; eating; estrogen replacement therapy; food; interviews as topic; new jersey; soy foods; waist-hip ratio
Journal Title: Cancer Causes & Control
Volume: 20
Issue: 7
ISSN: 0957-5243
Publisher: Springer  
Date Published: 2009-09-01
Start Page: 1117
End Page: 1127
Language: English
DOI: 10.1007/s10552-009-9336-9
PUBMED: 19353280
PROVIDER: scopus
PMCID: PMC2761755
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: CCCNE" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Camelia S Sima
    204 Sima
  2. Sara H Olson
    214 Olson
  3. Robert Soslow
    655 Soslow
  4. Ann G Zauber
    225 Zauber
  5. Katie Pulick
    5 Pulick