Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer Journal Article


Authors: Al-Ahmadie, H. A.; Iyer, G.; Lee, B. H.; Scott, S. N.; Mehra, R.; Bagrodia, A.; Jordan, E. J.; Gao, S. P.; Ramirez, R.; Cha, E. K.; Desai, N. B.; Zabor, E. C.; Ostrovnaya, I.; Gopalan, A.; Chen, Y. B.; Fine, S. W.; Tickoo, S. K.; Gandhi, A.; Hreiki, J.; Viale, A.; Arcila, M. E.; Dalbagni, G.; Rosenberg, J. E.; Bochner, B. H.; Bajorin, D. F.; Berger, M. F.; Reuter, V. E.; Taylor, B. S.; Solit, D. B.
Article Title: Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer
Abstract: Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.
Keywords: urothelial carcinoma; human breast; framework; deletions; poor-prognosis; gastric-cancer; dna-sequencing data
Journal Title: Nature Genetics
Volume: 48
Issue: 4
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 2016-04-01
Start Page: 356
End Page: 358
Language: English
ACCESSION: WOS:000372908800006
DOI: 10.1038/ng.3503
PROVIDER: wos
PMCID: PMC4827439
PUBMED: 26901067
Notes: Article -- Source: Wos
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MSK Authors
  1. Dean Bajorin
    516 Bajorin
  2. Guido Dalbagni
    274 Dalbagni
  3. David Solit
    553 Solit
  4. Satish K Tickoo
    398 Tickoo
  5. Anuradha Gopalan
    328 Gopalan
  6. Gopakumar Vasudeva Iyer
    173 Iyer
  7. Yingbei Chen
    279 Chen
  8. Emily Craig Zabor
    162 Zabor
  9. Neil B Desai
    35 Desai
  10. Bernard Bochner
    367 Bochner
  11. Agnes Viale
    216 Viale
  12. Sizhi Gao
    33 Gao
  13. Michael Forman Berger
    501 Berger
  14. Samson W Fine
    370 Fine
  15. Maria Eugenia Arcila
    464 Arcila
  16. Victor Reuter
    1074 Reuter
  17. Barry Stephen Taylor
    195 Taylor
  18. Jonathan Eric Rosenberg
    310 Rosenberg
  19. Sasinya Neka Scott
    69 Scott
  20. Ricardo   Ramirez
    19 Ramirez
  21. Eugene K. Cha
    68 Cha
  22. Anupama   Gandhi
    12 Gandhi
  23. Emmet John Jordan
    43 Jordan
  24. Byron Hing Lung Lee
    14 Lee
  25. Joseph   Hreiki
    5 Hreiki