Authors: | Al-Ahmadie, H. A.; Iyer, G.; Lee, B. H.; Scott, S. N.; Mehra, R.; Bagrodia, A.; Jordan, E. J.; Gao, S. P.; Ramirez, R.; Cha, E. K.; Desai, N. B.; Zabor, E. C.; Ostrovnaya, I.; Gopalan, A.; Chen, Y. B.; Fine, S. W.; Tickoo, S. K.; Gandhi, A.; Hreiki, J.; Viale, A.; Arcila, M. E.; Dalbagni, G.; Rosenberg, J. E.; Bochner, B. H.; Bajorin, D. F.; Berger, M. F.; Reuter, V. E.; Taylor, B. S.; Solit, D. B. |
Article Title: | Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer |
Abstract: | Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration. |
Keywords: | urothelial carcinoma; human breast; framework; deletions; poor-prognosis; gastric-cancer; dna-sequencing data |
Journal Title: | Nature Genetics |
Volume: | 48 |
Issue: | 4 |
ISSN: | 1061-4036 |
Publisher: | Nature Publishing Group |
Date Published: | 2016-04-01 |
Start Page: | 356 |
End Page: | 358 |
Language: | English |
ACCESSION: | WOS:000372908800006 |
DOI: | 10.1038/ng.3503 |
PROVIDER: | wos |
PMCID: | PMC4827439 |
PUBMED: | 26901067 |
Notes: | Article -- Source: Wos |