Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer Journal Article


Authors: Al-Ahmadie, H. A.; Iyer, G.; Lee, B. H.; Scott, S. N.; Mehra, R.; Bagrodia, A.; Jordan, E. J.; Gao, S. P.; Ramirez, R.; Cha, E. K.; Desai, N. B.; Zabor, E. C.; Ostrovnaya, I.; Gopalan, A.; Chen, Y. B.; Fine, S. W.; Tickoo, S. K.; Gandhi, A.; Hreiki, J.; Viale, A.; Arcila, M. E.; Dalbagni, G.; Rosenberg, J. E.; Bochner, B. H.; Bajorin, D. F.; Berger, M. F.; Reuter, V. E.; Taylor, B. S.; Solit, D. B.
Article Title: Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer
Abstract: Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.
Keywords: urothelial carcinoma; human breast; framework; deletions; poor-prognosis; gastric-cancer; dna-sequencing data
Journal Title: Nature Genetics
Volume: 48
Issue: 4
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 2016-04-01
Start Page: 356
End Page: 358
Language: English
ACCESSION: WOS:000372908800006
DOI: 10.1038/ng.3503
PROVIDER: wos
PMCID: PMC4827439
PUBMED: 26901067
Notes: Article -- Source: Wos
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MSK Authors
  1. Dean Bajorin
    411 Bajorin
  2. Guido Dalbagni
    251 Dalbagni
  3. David Solit
    435 Solit
  4. Satish K Tickoo
    369 Tickoo
  5. Anuradha Gopalan
    274 Gopalan
  6. Gopakumar Vasudeva Iyer
    126 Iyer
  7. Yingbei Chen
    221 Chen
  8. Emily Craig Zabor
    131 Zabor
  9. Neil B Desai
    35 Desai
  10. Bernard Bochner
    324 Bochner
  11. Agnes Viale
    205 Viale
  12. Sizhi Gao
    29 Gao
  13. Michael Forman Berger
    386 Berger
  14. Samson W Fine
    316 Fine
  15. Maria Eugenia Arcila
    343 Arcila
  16. Victor Reuter
    912 Reuter
  17. Barry Stephen Taylor
    141 Taylor
  18. Jonathan Eric Rosenberg
    225 Rosenberg
  19. Sasinya Neka Scott
    66 Scott
  20. Ricardo   Ramirez
    19 Ramirez
  21. Eugene K. Cha
    58 Cha
  22. Anupama   Gandhi
    12 Gandhi
  23. Emmet John Jordan
    29 Jordan
  24. Byron Hing Lung Lee
    14 Lee
  25. Joseph   Hreiki
    5 Hreiki