Safety of contralateral submandibular gland sparing in locally advanced oropharyngeal cancers: A multicenter review Journal Article
| Authors: | Robin, T. P.; Gan, G. N.; Tam, M.; Westerly, D.; Riaz, N.; Karam, S. D.; Lee, N.; Raben, D. |
| Article Title: | Safety of contralateral submandibular gland sparing in locally advanced oropharyngeal cancers: A multicenter review |
| Abstract: | Background. Previous groups have shown contralateral submandibular gland sparing to improve xerostomia with safe outcomes, but primarily in early-stage disease. In this study, we present a large cohort of patients with locally advanced head and neck cancer that underwent contralateral submandibular gland-sparing radiotherapy, to demonstrate feasibility and safety specifically in patients with locally advanced disease. Methods. We retrospectively analyzed patients who were treated prospectively with contralateral submandibular gland sparing. Only patients who underwent bilateral neck radiotherapy with contralateral submandibular gland doses <39 Gy were included. Results. We identified 71 patients. Approximately 80% of patients had >= N2b disease. The contralateral submandibular gland mean dose was 33 Gy and, at a median follow-up of 27.3 months, no patients experienced treatment failure in the contralateral level IB lymph nodes. Conclusion. Xerostomia remains a significant morbidity despite parotid sparing and can be minimized further by contralateral submandibular gland sparing. These data provide important preliminary evidence that contralateral submandibular gland sparing is feasible and may be safe even in locally advanced cancers. (C) 2015 Wiley Periodicals, Inc. |
| Keywords: | survival; head and neck cancer; intensity-modulated radiotherapy; xerostomia; salivary glands; metastases; quality-of-life; neck-cancer; prevention; head; squamous-cell-carcinoma; intensity-modulated radiation therapy (imrt); submandibular gland; salivary-gland; radiation-induced xerostomia |
| Journal Title: | Head & Neck |
| Volume: | 38 |
| Issue: | 4 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2016-04-01 |
| Start Page: | 506 |
| End Page: | 511 |
| Language: | English |
| ACCESSION: | WOS:000372722900009 |
| DOI: | 10.1002/hed.23928 |
| PROVIDER: | wos |
| PUBMED: | 25482748 |
| Notes: | Review -- Source: Wos |
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