Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer Journal Article
| Authors: | Kreymborg, K.; Haak, S.; Murali, R.; Wei, J.; Waitz, R.; Gasteiger, G.; Savage, P. A.; Van Den Brink, M. R. M.; Allison, J. P. |
| Article Title: | Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer |
| Abstract: | The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant. © 2015 AACR. |
| Journal Title: | Cancer Immunology Research |
| Volume: | 3 |
| Issue: | 8 |
| ISSN: | 2326-6066 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2015-08-01 |
| Start Page: | 849 |
| End Page: | 854 |
| Language: | English |
| DOI: | 10.1158/2326-6066.cir-15-0100 |
| PROVIDER: | scopus |
| PUBMED: | 26122284 |
| PMCID: | PMC5939565 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2016 -- Source: Scopus |
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