Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer Journal Article


Authors: Kreymborg, K.; Haak, S.; Murali, R.; Wei, J.; Waitz, R.; Gasteiger, G.; Savage, P. A.; Van Den Brink, M. R. M.; Allison, J. P.
Article Title: Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer
Abstract: The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant. © 2015 AACR.
Journal Title: Cancer Immunology Research
Volume: 3
Issue: 8
ISSN: 2326-6066
Publisher: American Association for Cancer Research  
Date Published: 2015-08-01
Start Page: 849
End Page: 854
Language: English
DOI: 10.1158/2326-6066.cir-15-0100
PROVIDER: scopus
PUBMED: 26122284
DOI/URL:
Notes: Article -- Export Date: 2 May 2016 -- Source: Scopus
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MSK Authors
  1. Rebecca Waitz
    13 Waitz
  2. James P Allison
    129 Allison
  3. Rajmohan Murali
    156 Murali