B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma Journal Article


Authors: Zhou, Z.; Luther, N.; Ibrahim, G. M.; Hawkins, C.; Vibhakar, R.; Handler, M. H.; Souweidane, M. M.
Article Title: B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma
Abstract: Diffuse intrinsic pontine glioma (DIPG) is a brain cancer with a median survival of only 1 year. Lack of molecular characterization of this tumor impedes the development of novel therapies. Membrane protein B7-H3, aka CD276, involved in interactions with host defenses in certain cancers, has been shown to be over-expressed in the majority of malignant neuroectodermal tumors including adult high-grade glioma. Targeting B7-H3 with a monoclonal antibody has demonstrated safety and efficacy in the salvage treatment of stage IV childhood neuroblastoma, another neuroectodermal tumor. It thus stands to reason that B7-H3 might serve as a therapeutic target in DIPG. B7-H3 immunoreactivity was determined in DIPG and non-diffuse brainstem glioma specimens with immunohistochemistry. In addition, B7-H3 mRNA expression was evaluated with microarrays in another set of specimens. All of the nine (100 %) DIPG specimens were shown to be B7-H3 immunoreactive. In the non-diffuse brainstem glioma group, none of the eight WHO grade I specimens showed B7-H3 immunoreactivity and nine of the 24 WHO grade II specimens (37.5 %) showed B7-H3 immunoreactivity. The association between histological grade and B7-H3 immunoreactivity was statistically highly significant. B7-H3 mRNA expression was also significantly higher in DIPG samples than in normal brain and juvenile pilocytic astrocytoma (WHO grade I) specimens. In summary, B7-H3 is over-expressed in DIPG. Given the need for novel treatment in this disease, antibody-based immunotherapy against B7-H3 in DIPG warrants further investigation. © 2012 Springer Science+Business Media New York.
Keywords: child; preschool child; child, preschool; retrospective studies; genetics; nuclear magnetic resonance imaging; glioma; magnetic resonance imaging; metabolism; computer assisted tomography; gene expression profiling; tomography, x-ray computed; pathology; retrospective study; immunotherapy; infant; messenger rna; rna, messenger; oligonucleotide array sequence analysis; dna microarray; brain stem tumor; brain stem neoplasms; b7 antigen; diffuse intrinsic pontine glioma; b7-h3; cd276; cd276 protein, human; b7 antigens
Journal Title: Journal of Neuro-Oncology
Volume: 111
Issue: 3
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2013-02-01
Start Page: 257
End Page: 264
Language: English
DOI: 10.1007/s11060-012-1021-2
PUBMED: 23232807
PROVIDER: scopus
PMCID: PMC4700828
DOI/URL:
Notes: - "Export Date: 1 November 2013" - "CODEN: JNODD" - "Source: Scopus"
Altmetric Score
MSK Authors