'Biologic' level structures through chemistry: a total synthesis of a unimolecular pentavalent MUCI glycopeptide construct Journal Article
| Authors: | Lee, D.; Danishefsky, S. J. |
| Article Title: | 'Biologic' level structures through chemistry: a total synthesis of a unimolecular pentavalent MUCI glycopeptide construct |
| Abstract: | A convergent synthesis of a unimolecular pentavalent-MUC1 glycopeptide has been accomplished. A tandem repeat of unglycosylated human tumor-associated MUC1, a potential target for cancer immunotherapy, was incorporated into the known unimolecular pentavalent carbohydrate construct (5). This is an important step toward the development of a new fully synthetic anticancer vaccine candidate (1). © 2009 Elsevier Ltd. All rights reserved. |
| Keywords: | drug structure; drug synthesis; cancer vaccine; chemical structure; high performance liquid chromatography; mucin 1; drug conjugation; glycopeptide |
| Journal Title: | Tetrahedron Letters |
| Volume: | 50 |
| Issue: | 19 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2009-05-13 |
| Start Page: | 2167 |
| End Page: | 2170 |
| Language: | English |
| DOI: | 10.1016/j.tetlet.2009.02.138 |
| PROVIDER: | scopus |
| PMCID: | PMC3059311 |
| PUBMED: | 21423786 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: TELEA" - "Source: Scopus" |
