Acinic cell carcinoma of breast: Morphologic and immunohistochemical review of a rare breast cancer subtype Journal Article
| Authors: | Conlon, N.; Sadri, N.; Corben, A. D.; Tan, L. K. |
| Article Title: | Acinic cell carcinoma of breast: Morphologic and immunohistochemical review of a rare breast cancer subtype |
| Abstract: | Summary Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis-like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins. © 2015 Elsevier Inc.All rights reserved. |
| Keywords: | immunohistochemistry; morphology; molecular pathology; triple-negative breast cancer; acinic cell carcinoma of breast |
| Journal Title: | Human Pathology |
| Volume: | 51 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-05-01 |
| Start Page: | 16 |
| End Page: | 24 |
| Language: | English |
| DOI: | 10.1016/j.humpath.2015.12.014 |
| PROVIDER: | scopus |
| PUBMED: | 27067778 |
| PMCID: | PMC5027139 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 April 2016 -- Source: Scopus |
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