Evolution and biological roles of alternative 3'UTRs Journal Article


Author: Mayr, C.
Article Title: Evolution and biological roles of alternative 3'UTRs
Abstract: More than half of human genes use alternative cleavage and polyadenylation to generate alternative 3' untranslated region (3'UTR) isoforms. Most efforts have focused on transcriptome-wide mapping of alternative 3'UTRs and on the question of how 3'UTR isoform ratios may be regulated. However, it remains less clear why alternative 3'UTRs have evolved and what biological roles they play. This review summarizes our current knowledge of the functional roles of alternative 3'UTRs, including mRNA localization, mRNA stability, and translational efficiency. Recent work suggests that alternative 3'UTRs may also enable the formation of protein-protein interactions to regulate protein localization or to diversify protein functions. These recent findings open an exciting research direction for the investigation of new biological roles of alternative 3'UTRs. © 2015 Elsevier Ltd.
Keywords: protein localization; rna-binding protein; noncoding rna; protein-protein interactions; 3'utr; protein abundance; alternative polyadenylation; diversification of protein functions; multifunctionality; post-transcriptional gene regulation; rna granule
Journal Title: Trends in Cell Biology
Volume: 26
Issue: 3
ISSN: 0962-8924
Publisher: Elsevier Inc.  
Date Published: 2016-03-01
Start Page: 227
End Page: 237
Language: English
DOI: 10.1016/j.tcb.2015.10.012
PROVIDER: scopus
PUBMED: 26597575
PMCID: PMC4955613
DOI/URL:
Notes: Review -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Christine Mayr
    14 Mayr