Advanced unilateral retinoblastoma: The impact of ophthalmic artery chemosurgery on enucleation rate and patient survival at MSKCC Journal Article

   

Authors:	Abramson, D. H.; Fabius, A. W. M.; Issa, R.; Francis, J. H.; Marr, B. P.; Dunkel, I. J.; Gobin, Y. P.
Article Title:	Advanced unilateral retinoblastoma: The impact of ophthalmic artery chemosurgery on enucleation rate and patient survival at MSKCC
Abstract:	Purpose: To report on the influence of ophthalmic artery chemosurgery (OAC) on enucleation rates, ocular and patient survival from metastasis and impact on practice patterns at Memorial Sloan Kettering for children with advanced intraocular unilateral retinoblastoma. Patients and Methods: Single-center retrospective review of all unilateral retinoblastoma patients with advanced intraocular retinoblastoma treated at MSKCC between our introduction of OAC (May 2006) and December 2014. End points were ocular survival, patient survival from metastases and enucleation rates. Results: 156 eyes of 156 retinoblastoma patients were included. Primary enucleation rates have progressively decreased from a rate of >95% before OAC to 66.7% in the first year of OAC use to the present rate of 7.4%. The percent of patients receiving OAC has progressively increased from 33.3% in 2006 to 92.6%in 2014. Overall, ocular survival was significantly better in eyes treated with OAC in the years 2010-2014 compared to 2006-2009 (p = 0.023, 92.7%vs 68.0% ocular survival at 48 months). There have been no metastatic deaths in the OAC group but two patients treated with primary enucleation have died of metastatic disease. Conclusion: OAC was introduced in 2006 and its impact on patient management is profound. Enucleation rates have decreased from over 95% to less than 10%. Our ocular survival rate has also significantly and progressively improved since May 2006. Despite treating more advanced eyes rather then enucleating them patient survival has not been compromised (there have been no metastatic deaths in the OAC group). In our institution, enucleation is no longer the most common treatment for advanced unilateral retinoblastoma. © 2015 Abramson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal Title:	PLoS ONE
Volume:	10
Issue:	12
ISSN:	1932-6203
Publisher:	Public Library of Science
Date Published:	2015-12-28
Start Page:	e0145436
Language:	English
DOI:	10.1371/journal.pone.0145436
PROVIDER:	scopus
PMCID:	PMC4692433
PUBMED:	26709699
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84957050027&partnerID=40&md5=cae8bbed921976f46d12bfcec4a24d08
Notes:	Article -- Export Date: 3 March 2016 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/89422