Ophthalmic artery chemosurgery for eyes with advanced retinoblastoma Journal Article

Authors: Abramson, D. H.; Fabius, A. W. M.; Francis, J. H.; Marr, B. P.; Dunkel, I. J.; Brodie, S. E.; Escuder, A.; Gobin, Y. P.
Article Title: Ophthalmic artery chemosurgery for eyes with advanced retinoblastoma
Abstract: Background: Surgical removal of one or both eyes has been the most common way to treat children with retinoblastoma worldwide for more than 100 years. Ophthalmic artery chemosurgery (OAC) was introduced 10 years ago and it has been used as an alternative to enucleation for eyes with advanced retinoblastoma. The purpose of this report is to analyze our 9-year experience treating advanced retinoblastoma eyes with OAC. Materials and methods: Single-arm retrospective study from a single center of 226 eyes with eyes of retinoblastoma patients with advanced intraocular disease defined as both Reese-Ellsworth (RE) “Va” or ”Vb” and International Classification Retinoblastoma (ICRb) group “D” or ”E” (COG Classification). Ocular survival, patient survival, second cancers, and electroretinography (ERG) were assessed. Results: Ocular survival at five years for these advanced eyes was 70.2% (95% confidence interval, 57.3%–79.8%). When eyes were divided into groups either by RE classification or ICRb, no significant differences in ocular survival were seen. Ocular survival was significantly better in naïve compared to non-naïve eyes (80.2% vs 58.4%, p = 0.041). The ERG distribution was very similar before and after OAC treatment for the patient population that did not receive intravitreal chemotherapy. Three patients (1.5%) have developed metastatic retinoblastoma (previously reported) and were successfully treated (no deaths). Conclusion: Using OAC for advanced eyes (the majority of such eyes have been enucleated in the past) enables 70% 5-year ocular survival. Treated eyes have a similar ERG distribution before and after treatment. No patient has died of metastatic retinoblastoma. © 2017 Taylor & Francis.
Keywords: retinoblastoma; ophthalmic artery chemosurgery; electroretinography melphalan; intrarterial chemotherapy
Journal Title: Ophthalmic Genetics
Volume: 38
Issue: 1
ISSN: 1381-6810
Publisher: Taylor & Francis Group  
Date Published: 2017-01-01
Start Page: 16
End Page: 21
Language: English
DOI: 10.1080/13816810.2016.1244695
PROVIDER: scopus
PUBMED: 28095092
PMCID: PMC5475401
Notes: Article -- Export Date: 2 March 2017 -- Source: Scopus
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MSK Authors
  1. Brian Marr
    108 Marr
  2. Ira J Dunkel
    250 Dunkel
  3. Jasmine Helen Francis
    95 Francis
  4. David H Abramson
    247 Abramson
  5. Scott Brodie
    37 Brodie
  6. Armida Wanda Mathilde Fabius
    13 Fabius
  7. Pierre Gobin
    23 Gobin