Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: A pilot study Journal Article


Authors: Calzavara-Pinton, P. G.; Rossi, M. T.; Zanca, A.; Arisi, M.; Gonzalez, S.; Venturini, M.
Article Title: Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: A pilot study
Abstract: Background: The effects on the inflammatory and tanning responses of sunlight/UVR of several oral antioxidants are still unknown. Objective: Assess intensity, time course of the inflammatory, and tanning responses to increasing dosages of solar-simulated radiation (SSR) at baseline and after oral supplementation of an extract of Polypodium leucotomos (PLE). Methods: Ten healthy subjects underwent phototesting with SSR with a visual and spectrophotometrical assessment of the responses with or without daily oral supplementation of two tablets containing 240 mg of PLE for a total of 15 days. Results: Polypodium leucotomos supplementation induced a significant increase of the minimal erythema dose (MED), a faster recovery of the inflammation following the delivery of super-erythemal doses, and no significant changes of the minimal melanogenic dose (MMD). Spectrophotometric assessment of the Δa* in test areas exposed to equally doses of SSR did not show differences. Conclusions: Polypodium leucotomos supplementation increased the MED and induced a faster recovery of the inflammation and a stronger tanning response with no changes in the melanogenic threshold. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Keywords: inflammation; polypodium leucotomos; solar-simulated radiation; spectrophotometry; tanning
Journal Title: Photodermatology Photoimmunology and Photomedicine
Volume: 32
Issue: 1
ISSN: 0905-4383
Publisher: Blackwell Publishing  
Date Published: 2016-01-01
Start Page: 22
End Page: 27
Language: English
DOI: 10.1111/phpp.12209
PROVIDER: scopus
PUBMED: 26408963
DOI/URL:
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Salvador Gonzalez Rodriguez
    204 Rodriguez