Comparison of CT volumetric measurement with RECIST response in patients with lung cancer Journal Article

Authors: Hayes, S. A.; Pietanza, M. C.; O'Driscoll, D.; Zheng, J.; Moskowitz, C. S.; Kris, M. G.; Ginsberg, M. S.
Article Title: Comparison of CT volumetric measurement with RECIST response in patients with lung cancer
Abstract: Purpose To examine the correlations between uni-dimensional RECIST and volumetric measurements in patients with lung adenocarcinoma and to assess their association with overall survival (OS) and progression-free survival (PFS). Materials and methods In this study of patients receiving chemotherapy for lung cancer in the setting of a clinical trial, response was prospectively evaluated using RECIST 1.0. Retrospectively, volumetric measurements were recorded and response was assessed by two different volumetric methods at each followup CT scan using a semi-automated segmentation algorithm. We subsequently evaluated the correlation between the uni-dimensional RECIST measurements and the volumetric measurements and performed landmark analyses for OS and PFS at the completion of the first and second follow-ups. Kaplan-Meier curves together with log-rank tests were used to evaluate the association between the different response criteria and patient outcome. Results Forty-two patients had CT scans at baseline, after the first follow up scan and second followup scan, and then every 8 weeks. The uni-dimensional RECIST measurements and volumetric measurements were strongly correlated, with a Spearman correlation coefficient (ρ) of 0.853 at baseline, ρ = 0.861 at the first followup, ρ = 0.843 at the 2nd followup, and ρ = 0.887 overall between-subject. On first follow-up CT, partial responders and non responders as assessed by an "ellipsoid" volumetric criteria showed a significant difference in OS (p = 0.008, 1-year OS of 70% for partial responders and 46% for non responders). There was no difference between the groups when assessed by RECIST criteria on first follow-up CT (p = 0.841, 1-year OS rate of 64% for partial responders and 64% for non responders). Conclusion Volumetric response on first follow-up CT may better predict OS than RECIST response. Clinical relevance statement Assessment of tumor size and response is of utmost importance in clinical trials. Volumetric measurements may help to better predict OS than uni-dimensional RECIST criteria. © 2015 Elsevier Ireland Ltd.
Keywords: lung cancer; recist; response; computed tomography; volumetric
Journal Title: European Journal of Radiology
Volume: 85
Issue: 3
ISSN: 0720-048X
Publisher: Elsevier Ireland Ltd.  
Date Published: 2016-03-01
Start Page: 524
End Page: 533
Language: English
DOI: 10.1016/j.ejrad.2015.12.019
PROVIDER: scopus
PMCID: PMC4750046
PUBMED: 26860663
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Junting Zheng
    133 Zheng
  2. Michelle S Ginsberg
    159 Ginsberg
  3. Chaya S. Moskowitz
    173 Moskowitz
  4. Maria C Pietanza
    115 Pietanza
  5. Mark Kris
    612 Kris
  6. Sara Anne Hayes
    19 Hayes