Abstract: |
Pediatric sarcomas are broadly defined into two main groups: (a) tumors that arise primarily in bone (osteosarcoma [OS] and Ewing sarcoma [ES], although the latter may also arise in extraosseous locations), and (b) tumors that arise in muscle and associated connective tissues (rhabdomyosarcoma [RMS] and the larger group of non-rhabdo soft tissue sarcomas [NRSTS]). Collectively, these tumors account for fewer than 1500 cases in children and adolescents in the USA, with an annual incidence of about 440 cases of OS, 400 cases of RMS, 250 cases of ES, and 200 cases of NRSTS [1, 2]. This chapter will focus on the three most common tumor types-RMS, OS, and ES. © Springer International Publishing Switzerland 2016. |