Children's Oncology Group's 2023 blueprint for research: Soft tissue sarcomas Guidelines
| Authors: | Oberoi, S.; Crane, J. N.; Haduong, J. H.; Rudzinski, E. R.; Wolden, S. L.; Dasgupta, R.; Linardic, C. M.; Weiss, A. R.; Venkatramani, R.; on behalf of the Children’s Oncology Group Soft Tissue Sarcoma Committee |
| Title: | Children's Oncology Group's 2023 blueprint for research: Soft tissue sarcomas |
| Abstract: | In the United States, approximately 850–900 children and adolescents each year are diagnosed with soft tissue sarcomas (STS). STS are divided into rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma STS (NRSTS). RMS and NRSTS are risk stratified into low-, intermediate-, and high-risk categories, with 5-year survival rates of approximately 90%, 50%–70%, and 20%, respectively. Recent key achievements from the Children's Oncology Group (COG) STS Committee include the identification of new molecular prognostic factors for RMS, development and validation of a novel risk stratification system for NRSTS, successful completion of a collaborative NRSTS clinical trial with adult oncology consortia, and collaborative development of the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT). Current COG trials for RMS are prospectively evaluating a new risk stratification system that incorporates molecular findings, de-intensification of therapy for a very low-risk subgroup, and augmented therapy approaches for intermediate- and high-risk RMS. Trials for NRSTS exploring novel targets and local control modalities are in development. © 2023 Wiley Periodicals LLC. |
| Keywords: | adolescent; adult; cancer survival; child; survival rate; clinical feature; cancer recurrence; cancer staging; outcome assessment; methodology; antineoplastic agent; cancer incidence; oncology; tumor marker; cancer research; cancer therapy; sarcoma; soft tissue sarcoma; medical oncology; rhabdomyosarcoma; children; soft tissue neoplasms; soft tissue tumor; desmoid tumor; clinical trial (topic); molecularly targeted therapy; cancer; humans; human; article; pediatric patient; non-rhabdomyosarcoma soft tissue sarcoma |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 70 |
| Issue: | Suppl. 6 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2023-09-01 |
| Start Page: | e30556 |
| Language: | English |
| DOI: | 10.1002/pbc.30556 |
| PUBMED: | 37430436 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
