Pseudotumor cerebri in acute promyelocytic leukemia patients on Intergroup Protocol 0129: Clinical description and recommendations for new diagnostic criteria Journal Article

   

Authors:	Coombs, C. C.; De Angelis, L. M.; Feusner, J. H.; Rowe, J. M.; Tallman, M. S.
Article Title:	Pseudotumor cerebri in acute promyelocytic leukemia patients on Intergroup Protocol 0129: Clinical description and recommendations for new diagnostic criteria
Abstract:	Background Multiple randomized trials have demonstrated a benefit for all-trans retinoic acid (ATRA) in patients with acute promyelocytic leukemia (APL). Pseudotumor cerebri (PTC) is an infrequently reported adverse effect of ATRA. Methods We examined the incidence, clinical course, and outcomes of patients with APL treated on Intergroup Protocol 0129 (I0129) who developed PTC. This trial evaluated the role of ATRA alone during induction and/or as maintenance therapy. Results Of the patients on trial, 240 received ATRA during induction, maintenance, or both; 8 had a clinical suspicion for PTC. Upon review of individual cases, this was felt to be "probable" in 4 patients, "possible" in 1 and "unlikely" in 3 due to lack of diagnostic criteria or presence of a more likely alternate diagnosis. Conclusions "Probable" PTC occurred in 1.7% of patients who received ATRA during induction and/or maintenance therapy. In agreement with previous reports, the incidence of PTC in APL patients receiving ATRA was higher in the pediatric population. Here, we discuss the method for diagnosing PTC in the setting of ATRA therapy and management strategies. © 2016 Elsevier Inc. All rights reserved.
Keywords:	neurotoxicity; acute promyelocytic leukemia; atra; all-trans retinoic acid; pseudotumor cerebri
Journal Title:	Clinical Lymphoma, Myeloma and Leukemia
Volume:	16
Issue:	3
ISSN:	2152-2650
Publisher:	Elsevier Inc.
Date Published:	2016-03-01
Start Page:	146
End Page:	151
Language:	English
DOI:	10.1016/j.clml.2015.11.018
PROVIDER:	scopus
PUBMED:	26724834
PMCID:	PMC5028896
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84958847668&partnerID=40&md5=702b5d9d53a9095f55de8d3a5ad51ccb
Notes:	Article -- Export Date: 3 March 2016 -- Source: Scopus

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