All-trans retinoic acid and late relapses in acute promyelocytic leukemia: Very long-term follow-up of the North American Intergroup Study I0129 Journal Article

   

Authors:	Douer, D.; Zickl, L. N.; Schiffer, C. A.; Appelbaum, F. R.; Feusner, J. H.; Shepherd, L.; Willman, C. L.; Bloomfield, C. D.; Paietta, E.; Gallagher, R. E.; Park, J. H.; Rowe, J. M.; Wiernik, P. H.; Tallman, M. S.
Article Title:	All-trans retinoic acid and late relapses in acute promyelocytic leukemia: Very long-term follow-up of the North American Intergroup Study I0129
Abstract:	We report a long-term follow-up (median 11.8 years) of the First North American Intergroup Study. 379 patients were randomized to induction with ATRA or to chemotherapy. All complete responders (CR) received consolidation chemotherapy, then randomized to 1 year ATRA or observation. 245 patients received ATRA sometime during the study: 195 (80%) achieved a CR. Nine (4.6%) relapsed late (>3 years from CR), the last occurred after 4.6 years; 7 of them were still alive after 5.5-15 years. In APL patients, late relapses are uncommon, and those who sustain CR >5 years can be considered cured. © 2013 Elsevier Ltd.
Keywords:	acute promyelocytic leukemia; late relapse; all-trans retinoic acid
Journal Title:	Leukemia Research
Volume:	37
Issue:	7
ISSN:	0145-2126
Publisher:	Elsevier Ltd
Date Published:	2013-07-01
Start Page:	795
End Page:	801
Language:	English
DOI:	10.1016/j.leukres.2013.03.001
PROVIDER:	scopus
PUBMED:	23528262
PMCID:	PMC4174301
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84878516956&partnerID=40&md5=8a1a37ddf3f44e4795acdf681013f07a
Notes:	--- - "Export Date: 1 July 2013" - "CODEN: LERED" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/43202