Abstract: |
Lung cancer is responsible for more deaths than any other cancers; most cancer-related deaths are due to the development of metastatic diseases rather than the progression of the primary tumors. Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies, which is associated with tumor progression, increased aggressiveness, enhanced metastatic potential, and poor prognosis. Hypoxic cancer cells are resistant to radiotherapy and some forms of chemotherapy. In this chapter, nuclear molecular imaging microenvironment including hypoxia, proliferation, and glucose metabolism in lung cancer metastases was discussed. © Springer Science+Business Media New York 2014. |