Hypoxia in microscopic tumors Journal Article
| Authors: | Li, X. F. ; O'Donoghue, J. A. |
| Article Title: | Hypoxia in microscopic tumors |
| Abstract: | Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, we recently showed that microscopic tumors less than 1 mm diameter were severely hypoxic. In this review, models and techniques for the study of hypoxia in microscopic tumors are discussed. © 2008 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | cancer chemotherapy; controlled study; human tissue; human cell; cancer growth; nonhuman; solid tumor; cancer radiotherapy; antineoplastic agent; neoplasms; animal cell; mouse; animals; animal tissue; oxygen; animal experiment; animal model; angiogenesis; tumor marker; animalia; hypoxia; pathological anatomy; neoplasm metastasis; short survey; 1 fluoro 3 (2 nitro 1 imidazolyl) 2 propanol f 18; pimonidazole; cell hypoxia; metastasis potential; 2 (2 nitro 1h imidazol 1 yl) n (2,2,3,3,3 pentafluoropropyl)acetamide; microscopic anatomy; micrometastases; 2 nitroimidazole; hypoxic resistance; microscopic tumors; 1 (1,1,1,3,3,3 hexafluoro 2 propoxy) 3 (2 nitro 1 imidazolyl) 2 propanol; iodo azomycingalactopyranoside |
| Journal Title: | Cancer Letters |
| Volume: | 264 |
| Issue: | 2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2008-06-18 |
| Start Page: | 172 |
| End Page: | 180 |
| Language: | English |
| DOI: | 10.1016/j.canlet.2008.02.037 |
| PUBMED: | 18384940 |
| PROVIDER: | scopus |
| PMCID: | PMC2460565 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: CALED" - "Source: Scopus" |
